Aldo-Keto Reductases and Toxicant Metabolism

Content: SECTION 1: GENERAL OVERVIEW ; 1. Introduction and Overview of the Aldo-Keto Reductase (AKR) Superfamily ; SECTION 2: AKRS AND ENDOGENOUS TOXICANTS ; 2. Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes Associated With Diabetic Complications ; 3. Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates ; 4. Role of Aldose Reductase in the Detoxification of Oxidized Phospholipids ; SECTION 3: AKRS AND EXOGENOUS TOXICANTS: TOBACCO RELATED CARCINOGENS ; 5. Competing Roles of Reductases in the Detoxification of the Tobacco-Specific Nitrosamine Ketone NNK ; 6. Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons ; 7. Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from Mouse ; 8 Efficient Synthesis of the Active Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons ; 9. Chemistry of PAH o-Quinones Generated by the AKR Pathway of PAH Activation ; 10. Analysis of Etheno-2'-Deoxyguanosine Adducts as Dosimeters of AKR Mediated Oxidative Stress ; SECTION 4: AKRS AND EXOGENOUS TOXICANTS: MYCOTOXINS, ALDEHYDES AND KETONES ; 11. Aflatoxin Aldehyde Reductases ; 12. Competing Reactions of Aflatoxin B1-Dialdehyde: Enzymatic Reduction vs Adduction with Lysine ; 13. The use of mammalian cell lines to investigate the role of aldo-keto reductases in the detoxication of aldehydes and ketones ; SECTION 5: AKRS, THE STRESS RESPONSE AND CELL SIGNALING ; 14. Aldose Reductase and the Stress Response ; 15. Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory Signals ; 16. Aldo-Keto Reductases in the Stress Response of the Budding Yeast Saccharomyces cerevisiae